Ketamine Addiction: Signs, Effects, & Treatment Options
Ketamine primarily exerts its analgesic, anesthetic, and psychomimetic effects via antagonism of NMDA receptors in the central nervous system (CNS). In the spinal cord’s dorsal horns, the antagonistic effect on NMDA receptors results in interference with pain transmission, leading to profound analgesia and prevention of central sensitization 16,17. These effects cumulatively lead to amnestic, analgesic, […]